Zinc(II)-The Overlooked Éminence Grise of Chloroquine's Fight against COVID-19?

Pharmaceuticals (Basel). 2020 Sep 1;13(9):228. doi: 10.3390/ph13090228.

Abstract

Zn(II) is an inhibitor of SARS-CoV-2's RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores-this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics.

Keywords: 2019-nCoV; COVID-19; SARS-CoV-2; Zn(II) ionophores; chloroquine; hydroxy- chloroquine.

Publication types

  • Review