Association between regional economic status and renal recovery of dialysis-requiring acute kidney injury among critically ill patients

Sci Rep. 2020 Sep 3;10(1):14573. doi: 10.1038/s41598-020-71540-7.


The association between regional economic status and the probability of renal recovery among patients with dialysis-requiring AKI (AKI-D) is unknown. The nationwide prospective multicenter study enrolled critically ill adult patients with AKI-D in four sampled months (October 2014, along with January, April, and July 2015) in Taiwan. The regional economic status was defined by annual disposable income per capita (ADIPC) of the cities the hospitals located. Among the 1,322 enrolled patients (67.1 ± 15.5 years, 36.2% female), 833 patients (63.1%) died, and 306 (23.1%) experienced renal recovery within 90 days following discharge. We categorized all patients into high (n = 992) and low economic status groups (n = 330) by the best cut-point of ADIPC determined by the generalized additive model plot. By using the Fine and Gray competing risk regression model with mortality as a competing risk factor, we found that the independent association between regional economic status and renal recovery persisted from model 1 (no adjustment), model 2 (adjustment to basic variables), to model 3 (adjustment to basic and clinical variables; subdistribution hazard ratio, 1.422; 95% confidence interval, 1.022-1.977; p = 0.037). In conclusion, high regional economic status was an independent factor for renal recovery among critically ill patients with AKI-D.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / economics*
  • Acute Kidney Injury / epidemiology
  • Acute Kidney Injury / therapy
  • Aged
  • Critical Illness / economics*
  • Critical Illness / epidemiology
  • Critical Illness / therapy
  • Economic Status*
  • Female
  • Hospital Mortality / trends*
  • Humans
  • Intensive Care Units
  • Male
  • Prospective Studies
  • Recovery of Function*
  • Renal Dialysis / economics*
  • Renal Dialysis / methods
  • Socioeconomic Factors
  • Taiwan / epidemiology