Cellular and molecular architecture of the intestinal stem cell niche

Nat Cell Biol. 2020 Sep;22(9):1033-1041. doi: 10.1038/s41556-020-0567-z. Epub 2020 Sep 3.


Intestinal stem and progenitor cells replicate and differentiate in distinct compartments, influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals were long obscure because intestinal mesenchyme was insufficiently characterised. In this Review, we discuss how recent mRNA profiles of mouse and human intestinal submucosa, coupled with fine-resolution microscopy and gene and cell disruptions, reveal a coherent picture of an organised tissue carrying cells with distinct molecular properties and functions.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Intestinal Mucosa / physiology*
  • Mesoderm / physiology
  • RNA, Messenger / genetics
  • Stem Cell Niche / physiology*
  • Wnt Proteins / genetics


  • RNA, Messenger
  • Wnt Proteins