Topical Cholesterol/Simvastatin Gel for the Treatment of CHILD Syndrome in an Adolescent

Int J Pharm Compd. 2020 Sep-Oct;24(5):367-369.


Congenital ichthyoses are a heterogeneous group of genetic skin disorders characterized by defects in the critical barrier function of the skin. These life-long conditions present a significant therapeutic challenge in dermatology. One important example is Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects, or CHILD syndrome. This is a rare congenital ichthyosis caused by mutations in cholesterol biosynthesis. With limited success, the cutaneous features of this condition have historically been managed symptomatically with emollients, topical keratolytics, and topical steroids. However, over the last decade, topical therapy directed at the pathogenesis of this condition has emerged as an effective treatment. Herein, we report a case of successful treatment of the cutaneous features of CHILD syndrome with compounded simvastatin and cholesterol gel and highlight the role of the compounding pharmacist in the care of patients with congenital ichthyosis.

MeSH terms

  • Abnormalities, Multiple / physiopathology*
  • Adolescent
  • Cholesterol / pharmacology*
  • Genetic Diseases, X-Linked / physiopathology*
  • Humans
  • Ichthyosiform Erythroderma, Congenital / physiopathology*
  • Limb Deformities, Congenital / physiopathology*
  • Simvastatin


  • Cholesterol
  • Simvastatin

Supplementary concepts

  • Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects