Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade

Emmanuel Cazottes; Claire Rougeulle

doi:10.1016/j.stem.2020.08.008

Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade

Cell Stem Cell. 2020 Sep 3;27(3):352-353. doi: 10.1016/j.stem.2020.08.008.

Authors

Emmanuel Cazottes¹, Claire Rougeulle²

Affiliations

¹ Université de Paris, Epigenetics and Cell Fate, CNRS, F-75006 Paris, France.
² Université de Paris, Epigenetics and Cell Fate, CNRS, F-75006 Paris, France. Electronic address: claire.rougeulle@u-paris.fr.

PMID: 32888422
DOI: 10.1016/j.stem.2020.08.008

Abstract

In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.

Publication types

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MeSH terms

Autocrine Communication
Chromosomes, Human, X
Germ Layers
Human Embryonic Stem Cells*
Humans
X Chromosome Inactivation* / genetics