Pathologic studies of total joint replacement

Orthop Clin North Am. 1988 Jul;19(3):611-25.


Articular endoprostheses are, in effect, foreign bodies designed to re-establish functioning articulations and are, therefore, capable of eliciting a local or systemic response to their presence. This article discusses the body's reactions to foreign bodies in general, and to endoprostheses in particular, and attempts to place those reactions into perspective regarding survival and failure of articular endoprostheses. The effects of size, shape, and composition of the materials used in the prosthetic components, and the mechanical factors acting on them to produce debris, are presented.

Publication types

  • Review

MeSH terms

  • Bone and Bones / drug effects
  • Bone and Bones / pathology*
  • Carcinogens
  • Drug Hypersensitivity / etiology
  • Foreign-Body Reaction / pathology*
  • Humans
  • Joint Prosthesis / adverse effects*
  • Metals / toxicity
  • Methylmethacrylates / toxicity*
  • Microscopy, Electron
  • Polyethylenes / toxicity
  • Prosthesis Failure


  • Carcinogens
  • Metals
  • Methylmethacrylates
  • Polyethylenes