Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing

Yuqian Qiao; Xiangmei Liu; Bo Li; Yong Han; Yufeng Zheng; Kelvin Wai Kwok Yeung; Changyi Li; Zhenduo Cui; Yanqin Liang; Zhaoyang Li; Shengli Zhu; Xianbao Wang; Shuilin Wu

doi:10.1038/s41467-020-18268-0

Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing

Nat Commun. 2020 Sep 7;11(1):4446. doi: 10.1038/s41467-020-18268-0.

Authors

Yuqian Qiao¹, Xiangmei Liu², Bo Li³, Yong Han³, Yufeng Zheng⁴, Kelvin Wai Kwok Yeung⁵, Changyi Li⁶, Zhenduo Cui¹, Yanqin Liang¹, Zhaoyang Li¹, Shengli Zhu¹, Xianbao Wang⁷, Shuilin Wu⁸

Affiliations

¹ School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin, 300072, China.
² Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China. liuxiangmei1978@163.com.
³ State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shanxi, China.
⁴ College of Engineering, State Key Laboratory for Turbulence and Complex System, Department of Materials Science and Engineering, Peking University, Beijing, 100871, China.
⁵ Department of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, 999077, China.
⁶ Stomatological Hospital, Tianjin Medical University, Tianjin, 300070, China.
⁷ Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China.
⁸ School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin, 300072, China. shuilinwu@tju.edu.cn.

Abstract

Owing to the poor penetration depth of light, phototherapy, including photothermal and photodynamic therapies, remains severely ineffective in treating deep tissue infections such as methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis. Here, we report a microwave-excited antibacterial nanocapturer system for treating deep tissue infections that consists of microwave-responsive Fe₃O₄/CNT and the chemotherapy agent gentamicin (Gent). This system, Fe₃O₄/CNT/Gent, is proven to efficiently target and eradicate MRSA-infected rabbit tibia osteomyelitis. Its robust antibacterial effectiveness is attributed to the precise bacteria-capturing ability and magnetic targeting of the nanocapturer, as well as the subsequent synergistic effects of precise microwaveocaloric therapy from Fe₃O₄/CNT and chemotherapy from the effective release of antibiotics in infection sites. The advanced target-nanocapturer of microwave-excited microwaveocaloric-chemotherapy with effective targeting developed in this study makes a major step forward in microwave therapy for deep tissue infections.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / therapeutic use
Drug Delivery Systems / methods
Drug Therapy / methods
Ferrosoferric Oxide / therapeutic use
Gentamicins / therapeutic use
Magnetite Nanoparticles / therapeutic use*
Methicillin-Resistant Staphylococcus aureus / drug effects
Microwaves / therapeutic use*
Nanotubes, Carbon
Osteomyelitis / drug therapy*
Osteomyelitis / microbiology
Rabbits
Staphylococcal Infections / drug therapy*

Substances

Anti-Bacterial Agents
Gentamicins
Magnetite Nanoparticles
Nanotubes, Carbon
Ferrosoferric Oxide