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. 2020 Oct;17(10):1095-1097.
doi: 10.1038/s41423-020-00523-5. Epub 2020 Sep 7.

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

Yang Li #  1 , Dan-Yun Lai #  1 , Hai-Nan Zhang #  1 , He-Wei Jiang #  1 , Xiaolong Tian #  2 , Ming-Liang Ma  1 , Huan Qi  1 , Qing-Feng Meng  1 , Shu-Juan Guo  1 , Yanling Wu  2 , Wei Wang  3 , Xiao Yang  4 , Da-Wei Shi  5 , Jun-Biao Dai  6 , Tianlei Ying  7 , Jie Zhou  8 , Sheng-Ce Tao  9
Affiliations

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

Yang Li et al. Cell Mol Immunol. 2020 Oct.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Linear epitope mapping of SARS-CoV-2 S protein and neutralizing activities of the elicited antibodies. a Heatmap of IgG antibody responses of 55 sera from COVID-19 convalescent patients and controls (healthy donors and lung cancer patients). FI fluorescence intensity. b Epitope mapping according to the response frequency. CI confidence interval. c Detailed structural information of the epitopes of the first hot areas on S protein (PDB: 6VYB). d Correlations of the antibody responses among the peptides for the first hot areas. e Detailed structural information of the epitopes of the second hot areas on S protein (PDB: 6VYB). f Correlations of the antibody responses among the peptides for the second hot areas. g Peptide microarray results for the enriched epitope-specific antibodies. h Neutralization assay with epitope-specific antibodies. Infection rates for each sample relative to that of the blank control are indicated. Triplicate experiments were performed, and the error bars indicate the SEM (standard error of the mean) value
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