Autophagy involvement in oncogenesis

Abstract

Various clinical and experimental findings have revealed the causal relationship between autophagy failure and oncogenesis, and several mechanisms have been suggested to explain this relationship. We recently proposed two additional mechanisms: centrosome number dysregulation and the failure of autophagic cell death. Here, we detail the mechanical relationship between autophagy failure and oncogenesis.

Keywords: alternative autophagy; autophagic cell death; autophagy; centrosome; oncogenesis.