[Preoperative nonspecific immunostimulation with Propionibacterium granulosum KP-45 in patients with colorectal cancer. A prospective randomized study]

Chirurg. 1988 Apr;59(4):272-8.
[Article in German]


The effect of preoperative unspecific immunomodulation with Propionibacterium granulosum KP-45 (P.g.) on postoperative complications and patient survival was evaluated in a prospectively randomized trial in patients with colorectal tumor resection. Patients of the therapy group (n = 51) received at least 3 days before operation an infusion of 10 mg P.g., patients of the control group (n = 49) were not treated at all. The wound infection rate and the number of re-explorations were significantly lower in the therapy group, however, patient survival and tumor recurrence rates were not positively affected by this P.g. pre-treatment.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Clinical Trials as Topic
  • Colonic Neoplasms / surgery
  • Colonic Neoplasms / therapy*
  • Combined Modality Therapy
  • Humans
  • Immunotherapy / methods*
  • Middle Aged
  • Neoplasm Recurrence, Local / immunology
  • Propionibacterium / immunology*
  • Random Allocation
  • Rectal Neoplasms / surgery
  • Rectal Neoplasms / therapy*
  • Surgical Wound Infection / immunology
  • Wound Healing