Regulation of mTORC2 Signaling

Genes (Basel). 2020 Sep 4;11(9):1045. doi: 10.3390/genes11091045.


Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity.

Keywords: Akt; mTOR; mTORC2 signaling; signaling crosstalk.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Proliferation*
  • Gene Expression Regulation*
  • Humans
  • MAP Kinase Signaling System*
  • Mechanistic Target of Rapamycin Complex 2 / genetics
  • Mechanistic Target of Rapamycin Complex 2 / metabolism*
  • Multiprotein Complexes / metabolism*
  • Phosphorylation


  • Multiprotein Complexes
  • Mechanistic Target of Rapamycin Complex 2