Current Scenario and Future Prospect in the Management of COVID-19

Curr Med Chem. 2021;28(2):284-307. doi: 10.2174/0929867327666200908113642.

Abstract

The COVID-19 pandemic continues to wreak havoc worldwide due to the lack of risk assessment, rapid spreading ability, and propensity to precipitate severe disease in comorbid conditions. In an attempt to fulfill the demand for prophylactic and treatment measures to intercept the ongoing outbreak, the drug development process is facing several obstacles and renaissance in clinical trials, including vaccines, antivirals, immunomodulators, plasma therapy, and traditional medicines. This review outlines the overview of SARS-CoV-2 infection, significant recent findings, and ongoing clinical trials concerning current and future therapeutic interventions for the management of advancing pandemic of the century.

Keywords: COVID-19; Convalescent Plasma; Cytokine Storm; Remdesivir; SARS-CoV-2; TCM; Vaccines.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / therapeutic use*
  • COVID-19 / therapy
  • COVID-19 Drug Treatment*
  • COVID-19 Serotherapy
  • COVID-19 Vaccines
  • Clinical Trials as Topic
  • Humans
  • Immunization, Passive
  • Immunologic Factors / therapeutic use
  • Medicine, Traditional
  • Pandemics

Substances

  • Antiviral Agents
  • COVID-19 Vaccines
  • Immunologic Factors