An auspicious triumph of recovery from dialysis-requiring acute kidney injury in COVID-19 in a patient with chronic kidney disease, α-1 antitrypsin deficiency, and liver transplant: A case report

Clin Nephrol. 2020 Dec;94(6):297-306. doi: 10.5414/CN110294.


We report a unique case of an immunosuppressed 67-year-old female with homozygous Z-allele mutation A1AT deficiency and liver transplant with baseline chronic kidney disease (CKD) stage IIIa with creatinine of 1 mg/dL and glomerular filtration rate (GFR) of 49 mL/min/1.73m2 ~ 6 months before the presentation. She presented with COVID-19 mediated hypoxic respiratory failure complicated by AKI requiring provisional renal replacement therapy with recovery of kidney function with a new baseline of creatinine of 1.6 - 1.8 mg/dL with GFR of 31 mL/min/1.73m2.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury*
  • Aged
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections*
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Immunocompromised Host
  • Liver Transplantation*
  • Pandemics*
  • Pneumonia, Viral*
  • Renal Dialysis
  • Renal Insufficiency, Chronic / complications*
  • SARS-CoV-2
  • alpha 1-Antitrypsin / genetics
  • alpha 1-Antitrypsin Deficiency / complications*


  • alpha 1-Antitrypsin