Renal colic is a common cause of pain; however, there have been few reports of treating this pain with regional anesthesia. We report on a 49-year-old man presenting with severe left flank pain resulting from a 4-mm stone in the left ureter. The pain was minimally responsive to intravenous opioids. Left-sided paravertebral blocks were performed at T7 and T9 with 10 mL bupivacaine 0.5% with epinephrine 2.5 µg/mL to each paravertebral space. The pain resolved over the following 30 minutes, and the patient was discharged home. No further pain was experienced before and while subsequently passing the stone.