Abstract
In experiments on rats, co-transplantation of olfactory ensheathing cells of the human olfactory mucosa and neural stem/progenitor cells from the same source into post-traumatic cysts of the spinal cord led to improvement of the motor activity of the hind limbs and reduced the size of the cysts in some animals by 4-12%. The transplantation of a combination of the olfactory mucosa cells is effective and can be used in preclinical trials for the treatment of spinal cord injuries.
Keywords:
cell therapy; human olfactory mucosa; neural stem/progenitor cells; olfactory ensheathing cells; post-traumatic cysts of spinal cord.
MeSH terms
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Animals
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Cell- and Tissue-Based Therapy / methods
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Cysts / pathology
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Cysts / physiopathology
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Cysts / therapy*
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Epithelial Cells / cytology
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Epithelial Cells / physiology
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Epithelial Cells / transplantation*
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Female
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Humans
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Motor Activity / physiology
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Neural Stem Cells / cytology
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Neural Stem Cells / physiology
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Neural Stem Cells / transplantation*
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Olfactory Mucosa / cytology
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Olfactory Mucosa / physiology
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Primary Cell Culture
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Rats
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Rats, Wistar
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Recovery of Function / physiology*
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Spheroids, Cellular / cytology
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Spheroids, Cellular / physiology
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Spheroids, Cellular / transplantation*
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Spinal Cord / pathology
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Spinal Cord / physiopathology
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Spinal Cord Injuries / pathology
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Spinal Cord Injuries / physiopathology
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Spinal Cord Injuries / therapy*
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Transplantation, Heterologous
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Treatment Outcome