A genome-wide association study revealed five SNPs affecting 8-month weight in sheep

Anim Genet. 2020 Dec;51(6):973-976. doi: 10.1111/age.12996. Epub 2020 Sep 10.

Abstract

Lamb weight at 8 months of age is an important trait in the sheep industry in terms of the onset of puberty around this age; however, knowledge of its effective genetic factors is limited. Therefore, a GWAS using the 50K SNP-Chip was performed on 96 Baluchi sheep to identify the genomic regions associated with 8-month weight. The results of the present study revealed five SNPs on chromosomes 4, 14 and 16 at 5% chromosome-wide significance level, jointly accounting for 0.95% of total genetic variance. Four genes - MTPN, HYDIN, LRGUK and ZFP90 - were found in 50 kb intervals around the significant SNPs, of which MTPN is involved in regulation of skeletal muscle growth. Our results may provide a new vision to identify the genomic regions affecting growth traits in sheep.

Keywords: GWAS; body weight; candidate gene; sheep.

MeSH terms

  • Animals
  • Body Weight / genetics*
  • Breeding
  • Female
  • Genetic Association Studies / veterinary*
  • Iran
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Pregnancy
  • Red Meat
  • Sheep, Domestic / genetics*
  • Sheep, Domestic / growth & development