Insights into glucocorticoid responses derived from omics studies

Pharmacol Ther. 2021 Feb;218:107674. doi: 10.1016/j.pharmthera.2020.107674. Epub 2020 Sep 8.

Abstract

Glucocorticoid drugs are commonly used in the treatment of several conditions, including autoimmune diseases, asthma and cancer. Despite their widespread use and knowledge of biological pathways via which they act, much remains to be learned about the cell type-specific mechanisms of glucocorticoid action and the reasons why patients respond differently to them. In recent years, human and in vitro studies have addressed these questions with genomics, transcriptomics and other omics approaches. Here, we summarize key insights derived from omics studies of glucocorticoid response, and we identify existing knowledge gaps related to mechanisms of glucocorticoid action that future studies can address.

Keywords: Epigenomics; Genomics; Glucocorticoids; Metabolomics; Proteomics; Transcriptomics.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Genomics
  • Glucocorticoids* / pharmacology
  • Humans

Substances

  • Glucocorticoids