Viral load of SARS-CoV-2 across patients and compared to other respiratory viruses

Microbes Infect. 2020 Nov-Dec;22(10):617-621. doi: 10.1016/j.micinf.2020.08.004. Epub 2020 Sep 7.

Abstract

RT-PCRs to detect SARS-CoV-2 RNA is key to manage the COVID-19 pandemic. We analyzed SARS-CoV-2 viral loads from 22'323 RT-PCR results according to samples types, gender, age, and health units. Viral load did not show any difference across age and appears to be a poor predictor of disease outcome. SARS-CoV-2 viral load showed similar high viral loads than the one observed for RSV and influenza B. The importance of viral load to predict contagiousness and to assess disease progression is discussed.

Keywords: COVID-19; Cycle threshold; Diagnostic; RT-PCR; SARS-CoV-2; Viral load.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • COVID-19 / diagnosis
  • COVID-19 / virology*
  • COVID-19 Nucleic Acid Testing
  • Child
  • Child, Preschool
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / virology*
  • Disease Progression
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Influenza B virus / isolation & purification
  • Influenza, Human / virology
  • Male
  • Middle Aged
  • Pandemics
  • Respiratory Syncytial Virus Infections / virology
  • Respiratory Syncytial Viruses / isolation & purification
  • SARS-CoV-2 / isolation & purification*
  • Serologic Tests / methods
  • Switzerland / epidemiology
  • Viral Load / statistics & numerical data*