Non-respondents in a post-myocardial infarction trial: characteristics and reasons for refusal

Acta Med Scand. 1988;223(6):537-42. doi: 10.1111/j.0954-6820.1988.tb17692.x.


We surveyed the 270 survivors of acute myocardial infarction who refused to participate in the Warfarin Re-Infarction Study (WARIS). Information on medical variables were derived from registration forms completed by hospital staff upon discharge, whereas data on a variety of health conditions and reasons for refusal were gathered by mailed questionnaires, 178 (66%) of which were returned. Some disparities were found when comparing non-respondents and participants, the former showing more potential bad risk factors. The diversities between participants and non-respondents are of yet unknown prognostic importance. However, the presence of such differences imply that information on characteristics of non-respondents in clinical trials is desirable in terms of generalizability of the trial results. Reasons stated for non-participation reflect poor motivation, low mobility and saturation with focusing on disease. A slight co-variation between social status and reasons for refusal was noted.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction* / drug therapy
  • Patient Compliance*
  • Prognosis
  • Random Allocation
  • Risk Factors