Review - Helicobacter, inflammation, immunology and vaccines

Helicobacter. 2020 Sep;25 Suppl 1:e12737. doi: 10.1111/hel.12737.

Abstract

Understanding the mechanisms involved in induction and regulation of the immune and inflammatory response to Helicobacter pylori is extremely important in determining disease outcomes. H pylori expresses a plethora of factors that influence the host response. Vaccines against H pylori are desperately needed for the prevention of gastric carcinogenesis, especially with the increasing trends in antimicrobial resistance. This review summarizes some important findings, published between 1 April 2019 and 31 March 2020, in the areas of H pylori-mediated inflammation, immunity and vaccines.

Keywords: Helicobacter pylori; adaptive immunity; cytokines; inflammation; innate immunity; vaccines.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Vaccines / immunology*
  • Gastric Mucosa / immunology*
  • Helicobacter Infections* / immunology
  • Helicobacter Infections* / prevention & control
  • Helicobacter pylori
  • Humans
  • Immunity, Innate*
  • Inflammation / immunology*

Substances

  • Bacterial Vaccines