In vitro evaluation of the antitumoral and antiangiogenic effects of extracts from Spondias mombin L. leaves

Cristina Rey-Blanes; Yalina Pérez-Portero; Humberto J Morris-Quevedo; Virginia Casas; Roberto Abdala; Ana R Quesada; Beatriz Martínez-Poveda; Miguel Ángel Medina

doi:10.1016/j.biopha.2020.110716

In vitro evaluation of the antitumoral and antiangiogenic effects of extracts from Spondias mombin L. leaves

Biomed Pharmacother. 2020 Nov:131:110716. doi: 10.1016/j.biopha.2020.110716. Epub 2020 Sep 10.

Authors

Cristina Rey-Blanes¹, Yalina Pérez-Portero², Humberto J Morris-Quevedo³, Virginia Casas⁴, Roberto Abdala⁵, Ana R Quesada⁶, Beatriz Martínez-Poveda⁷, Miguel Ángel Medina⁸

Affiliations

¹ Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071, Málaga, Spain.
² Facultad de Ciencias Naturales y Exactas, Departamento de Biología, Universidad de Oriente, Santiago de Cuba, Cuba.
³ Centro de Estudios de Biotecnología Industrial (CEBI), Universidad de Oriente, Santiago de Cuba, Cuba.
⁴ Universidad de Málaga, Andalucía Tech, Departamento de Ecología y Geología, Facultad de Ciencias, E-29071, Málaga, Spain.
⁵ Universidad de Málaga, Andalucía Tech, Departamento de Ecología y Geología, Facultad de Ciencias, E-29071, Málaga, Spain; IBYDA (Institute of Blue Biotechnology and Development), Málaga, Spain.
⁶ Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071, Málaga, Spain; IBIMA (Biomedical Research Institute of Málaga), E-29071, Málaga, Spain; CIBER de Enfermedades Raras (CIBERER), E-29071, Málaga, Spain.
⁷ Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071, Málaga, Spain; IBIMA (Biomedical Research Institute of Málaga), E-29071, Málaga, Spain; CIBER de Enfermedades Vasculares (CIBERCV), Madrid, Spain.
⁸ Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071, Málaga, Spain; IBIMA (Biomedical Research Institute of Málaga), E-29071, Málaga, Spain; CIBER de Enfermedades Raras (CIBERER), E-29071, Málaga, Spain. Electronic address: medina@uma.es.

PMID: 32920516
DOI: 10.1016/j.biopha.2020.110716

Abstract

The traditional ethnobotanic and pharmacologic use of Spondias mombin L. samples includes a wide range of applications. In the present study, new antiangiogenic and antitumor effects of two types of extracts from Spondias mombin L. leaves have been demonstrated by using a number of in vitro assays in both endothelial and human cancer and non cancer cells.

Keywords: Angiogenesis; Antiangiogenic effects; Antitumor effects; Spondias mombin.

MeSH terms

Anacardiaceae* / chemistry
Angiogenesis Inhibitors / pharmacology*
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Cycle / drug effects
Cell Line, Tumor
Cell Movement / drug effects
Cell Survival / drug effects
Endothelial Cells / drug effects
Humans
Plant Extracts / pharmacology*
Plant Leaves / chemistry

Substances

Angiogenesis Inhibitors
Antineoplastic Agents, Phytogenic
Plant Extracts