Laser Ablation for Cerebral Metastases

Neurosurg Clin N Am. 2020 Oct;31(4):537-547. doi: 10.1016/ Epub 2020 Aug 10.


Laser interstitial thermal therapy is a minimally invasive surgical alternative to craniotomy that uses laser light through a fiber optic probe placed within a target lesion to create thermal tissue damage, resulting in cellular death. It is used in neuro-oncology to treat inaccessible lesions and obviate morbidity in high-risk patients. Overall complication rates and outcome measures are comparable with those seen in radiation and/or craniotomy. Laser interstitial thermal therapy can be an effective option for recurrent brain metastases. Prospective, randomized trials must be performed to evaluate the efficacy of laser interstitial thermal therapy as a primary treatment for brain metastases.

Keywords: Brain metastasis; Brain tumor; Laser ablation; Laser interstitial thermal therapy; Metastases; Minimally invasive surgery; Neuro-oncology; Oncology.

Publication types

  • Systematic Review

MeSH terms

  • Brain / surgery
  • Brain Neoplasms / surgery*
  • Humans
  • Laser Therapy / instrumentation
  • Laser Therapy / methods*
  • Minimally Invasive Surgical Procedures / methods
  • Treatment Outcome