Sellar Metastases: Diagnosis and Management

Neurosurg Clin N Am. 2020 Oct;31(4):651-658. doi: 10.1016/ Epub 2020 Aug 14.


Sellar metastases account for 0.87% of all intracranial metastases. They are usually asymptomatic and can be the first manifestations of some occult malignancy. The diagnosis is made mainly during the screening of patients with known primary lesions or can present with neurologic or hormonal changes related to compression or invasion of surrounding structures. Differentiating these lesions from other more common lesions such as pituitary adenoma maybe difficult. Management is mainly aimed at the primary lesion and is palliative to improve quality of life or for pathologic confirmation.

Keywords: Metastases; Pituitary; Sella; Skull base surgery.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / pathology
  • Disease Progression
  • Endocrine System Diseases / etiology
  • Humans
  • Lung Neoplasms / pathology
  • Pituitary Neoplasms / complications
  • Pituitary Neoplasms / diagnosis*
  • Pituitary Neoplasms / secondary
  • Pituitary Neoplasms / therapy*
  • Treatment Outcome