Brave new world revisited: Focus on nanomedicine

Biochem Biophys Res Commun. 2020 Nov 26;533(1):36-49. doi: 10.1016/j.bbrc.2020.08.046. Epub 2020 Sep 10.

Abstract

Nanomedicine is at a crossroads: with relatively few success stories in terms of clinical translation despite more and more research on increasingly sophisticated nanomaterials, it is important to consider whether we are on the right track. Indeed, it is crucial that we address the fact that while considerable efforts are being made to overcome barriers to translation from the bench to the clinic, scientists are still struggling to decipher fundamental aspects of nanomaterial interactions with biological systems. We believe that a key to the successful adoption of nanomedicines in oncology and beyond lies in a deeper understanding of underlying biological processes and in decoding interactions between engineered nanomaterials and biological systems. Here we provide an overview of progress in nanomedicine during the past 5 years.

Keywords: Cardiovascular disease; Nanomedicine; Nanosafety; Oncology; Theranostics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Magnetite Nanoparticles / adverse effects
  • Magnetite Nanoparticles / chemistry
  • Magnetite Nanoparticles / therapeutic use
  • Nanomedicine / methods*
  • Nanostructures / adverse effects
  • Nanostructures / chemistry
  • Nanostructures / therapeutic use*
  • Nanotechnology / methods
  • Neoplasms / therapy

Substances

  • Magnetite Nanoparticles