Immunotherapy with heat shock protein 96 to treat gliomas

Chin Neurosurg J. 2020 Sep 3:6:31. doi: 10.1186/s41016-020-00211-3. eCollection 2020.


Heat shock protein 96 (gp96) is a highly conserved protein in the endoplasmic reticulum. The functions of gp96 include promoting the oncogenesis and progression of glioma. In addition, tumor-derived gp96 can activate anti-tumor immune. Therefore, this protein was used to generate an anti-tumor vaccine and widely applied to glioma therapy. This review summarizes the mechanisms of gp96 in glioma oncogenesis and clinical trials of the gp96 tumor vaccine in glioma treatment.

Keywords: Glioma; Oncogenesis; Tumor vaccine; gp96.

Publication types

  • Review