Ghrelin and vascular protection

James T Pearson; Mikiyasu Shirai; Vijayakumar Sukumaran; Cheng-Kun Du; Hirotsugu Tsuchimochi; Takashi Sonobe; Mark T Waddingham; Rajesh Katare; Daryl O Schwenke

doi:10.1530/VB-19-0024

Ghrelin and vascular protection

Vasc Biol. 2019 Sep 5;1(1):H97-H102. doi: 10.1530/VB-19-0024. eCollection 2019.

Authors

James T Pearson^{1

2}, Mikiyasu Shirai¹, Vijayakumar Sukumaran¹, Cheng-Kun Du¹, Hirotsugu Tsuchimochi¹, Takashi Sonobe¹, Mark T Waddingham¹, Rajesh Katare³, Daryl O Schwenke³

Affiliations

¹ Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
² Department of Physiology and Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
³ Department of Physiology, HeartOtago, School of Biomedical Sciences University of Otago, Dunedin, New Zealand.

Abstract

Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function by maintaining the balance of vasodilator-vasoconstrictor factors, inhibiting inflammatory cytokine production and immune cell recruitment to sites of vascular injury and by promoting angiogenesis.

Keywords: GHS-R1a; angiogenesis; ghrelin; inflammation; vasodilation.

Publication types

Review