Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center

Methods Mol Biol. 2021;2194:1-19. doi: 10.1007/978-1-0716-0849-4_1.


Translational bioinformatics for therapeutic discovery requires the infrastructure of clinical informatics. In this chapter, we describe the clinical informatics components needed for successful implementation of translational research at a cancer center. This chapter is meant to be an introduction to those clinical informatics concepts that are needed for translational research. For a detailed account of clinical informatics, the authors will guide the reader to comprehensive resources. We provide examples of workflows from Moffitt Cancer Center led by Drs. Perkins and Markowitz. This perspective represents an interesting collaboration as Dr. Perkins is the Chief Medical Information Officer and Dr. Markowitz is a translational researcher in Melanoma with an active informatics component to his laboratory to study the mechanisms of resistance to checkpoint blockade and an active member of the clinical informatics team.

Keywords: Bioinformatics; Clinical informatics; Oncology operational processes; Translational research.

MeSH terms

  • Biomedical Research / methods*
  • Cancer Care Facilities / organization & administration
  • Computational Biology / organization & administration*
  • Humans
  • Medical Informatics / methods*
  • Medical Informatics / organization & administration*
  • Medical Oncology / methods*
  • Translational Medical Research / methods*
  • Translational Medical Research / organization & administration*
  • Workflow