Prospective evaluation of the lymph node proteome in dogs with multicentric lymphoma supplemented with sulforaphane

J Vet Intern Med. 2020 Sep;34(5):2036-2047. doi: 10.1111/jvim.15898. Epub 2020 Sep 14.

Abstract

Background: Lymphoma (LSA) is a common malignancy in dogs. Epigenetic changes are linked to LSA pathogenesis and poor prognosis in humans, and LSA pathogenesis in dogs. Sulforaphane (SFN), an epigenetic-targeting compound, has recently gained interest in relation to cancer prevention and therapy.

Objective: Examine the impact of oral supplementation with SFN on the lymph node proteome of dogs with multicentric LSA.

Animals: Seven client-owned dogs with multicentric LSA.

Methods: Prospective, nonrandomized, noncontrolled study in treatment-naïve dogs with intermediate or large cell multicentric LSA. Lymph node cell aspirates were obtained before and after 7 days of oral supplementation with SFN, and analyzed via label-free mass spectrometry, immunoblots, and Gene Set Enrichment Analysis.

Results: There was no clinical response and no adverse events attributed to SFN. For individual dogs, the expression of up to 650 proteins changed by at least 2-fold (range, 2-100) after supplementation with SFN. When all dogs where analyzed together, 14 proteins were significantly downregulated, and 10 proteins were significantly upregulated after supplementation with SFN (P < .05). Proteins and gene sets impacted by SFN were commonly involved in immunity, response to oxidative stress, gene transcription, apoptosis, protein transport, maturation and ubiquitination.

Conclusions and clinical importance: Sulforaphane is associated with major changes in the proteome of neoplastic lymphocytes in dogs.

Keywords: cruciferous vegetables; epigenetic; immunity; isothiocyanate; lymphoma and lymphosarcoma; proteome.

MeSH terms

  • Animals
  • Dietary Supplements
  • Dog Diseases* / drug therapy
  • Dogs
  • Isothiocyanates
  • Lymph Nodes
  • Lymphoma* / drug therapy
  • Lymphoma* / veterinary
  • Prospective Studies
  • Proteome
  • Sulfoxides

Substances

  • Isothiocyanates
  • Proteome
  • Sulfoxides
  • sulforaphane