Milk and Fermented Milk Intake and Parkinson's Disease: Cohort Study

Nutrients. 2020 Sep 10;12(9):2763. doi: 10.3390/nu12092763.

Abstract

Milk and fermented milk consumption has been linked to health and mortality but the association with Parkinson's disease (PD) is uncertain. We conducted a study to investigate whether milk and fermented milk intakes are associated with incident PD. This cohort study included 81,915 Swedish adults (with a mean age of 62 years) who completed a questionnaire, including questions about milk and fermented milk (soured milk and yogurt) intake, in 1997. PD cases were identified through linkage with the Swedish National Patient and Cause of Death Registers. Multivariable-adjusted hazard ratios were obtained from Cox proportional hazards regression models. During a mean follow-up of 14.9 years, 1251 PD cases were identified in the cohort. Compared with no or low milk consumption (<40 mL/day), the hazard ratios of PD across quintiles of milk intake were 1.29 (95% CI 1.07, 1.56) for 40-159 mL/day, 1.19 (95% CI 0.99, 1.42) for 160-200 mL/day, 1.29 (95% CI 1.08, 1.53) for 201-400 mL/day, and 1.14 (95% CI 0.93, 1.40) for >400 mL/day. Fermented milk intake was not associated with PD. We found a weak association between milk intake and increased risk of PD but no dose-response relationship. Fermented milk intake was not associated with increased risk of PD.

Keywords: Parkinson’s disease; milk; risk factors.

MeSH terms

  • Aged
  • Animals
  • Cohort Studies
  • Diet Surveys
  • Drinking
  • Drinking Behavior
  • Female
  • Fermented Foods / adverse effects
  • Fermented Foods / statistics & numerical data*
  • Follow-Up Studies
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Milk / adverse effects
  • Milk / chemistry
  • Milk / statistics & numerical data*
  • Parkinson Disease / epidemiology*
  • Parkinson Disease / etiology
  • Proportional Hazards Models
  • Risk Factors
  • Surveys and Questionnaires
  • Sweden / epidemiology