Abstract
We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.
Keywords:
SARS-CoV-2; antibody; neutralization; non-severe; severe.
MeSH terms
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Adult
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Aged
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Antibodies, Neutralizing / blood*
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Antibodies, Neutralizing / immunology
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Antibodies, Viral / blood*
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Antibodies, Viral / immunology
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Antigens, Viral / immunology
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Betacoronavirus / immunology*
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COVID-19
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Coronavirus Infections / immunology
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Female
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Humans
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Male
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Middle Aged
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Neutralization Tests
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Nucleocapsid / immunology*
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Pandemics
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Pneumonia, Viral / immunology
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SARS-CoV-2
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Severity of Illness Index
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Spike Glycoprotein, Coronavirus / immunology*
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Viral Envelope Proteins / immunology
Substances
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Antibodies, Neutralizing
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Antibodies, Viral
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Antigens, Viral
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Spike Glycoprotein, Coronavirus
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Viral Envelope Proteins