An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer

J Cancer Res Ther. Jul-Sep 2020;16(4):718-725. doi: 10.4103/0973-1482.189237.

Abstract

Aim of study: There were many reports published on the relationship between glutathione S-transferase T1 (GSTT1) null/presence gene polymorphism and the risk of lung cancer in these years. In previous, we conducted a meta-analysis to evaluate the relationship between GSTT1 null/presence gene polymorphism and the risk of lung cancer. This study was conducted to update it.

Materials and methods: The association studies were identified from PubMed and Cochrane Library on March 1, 2016.

Results: Sixty-three reports were recruited into this meta-analysis for the association of null genotype of GSTT1 with lung cancer susceptibility, consisting of 21,220 patients with lung cancer and 21,496 controls. There was a marked association between GSTT1 null genotype and lung cancer risk in overall populations and in Asians (overall populations: Odds ratio [OR] = 1.17, 95% confidence interval [95% CI]: 1.07-1.28, P = 0.006; Asians: OR = 1.41, 95% CI: 1.23-1.62, P < 0.00001). However, GSTT1 null genotype was not associated with the risk of lung cancer in Caucasians, Brazilian population, and Africans.

Conclusion: GSTT1 null genotype is associated with the lung cancer risk in overall populations and in Asians.

Keywords: Gene polymorphism; glutathione S-transferase T1; lung cancer; updated meta-analysis.

Publication types

  • Meta-Analysis

MeSH terms

  • Asians / genetics
  • Genetic Predisposition to Disease
  • Glutathione Transferase / genetics*
  • Humans
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / enzymology
  • Lung Neoplasms / ethnology
  • Lung Neoplasms / genetics*
  • Polymorphism, Genetic
  • Prognosis
  • Risk Factors
  • Whites / genetics

Substances

  • glutathione S-transferase T1
  • Glutathione Transferase