Anthocyanins regulate serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes: a randomized controlled trial

Eur J Nutr. 2021 Jun;60(4):1935-1944. doi: 10.1007/s00394-020-02379-x. Epub 2020 Sep 15.

Abstract

Background: Epidemiological studies have suggested that adipsin and visfatin are associated with the development of type 2 diabetes. This is the first study to investigate the effects of supplementation with purified anthocyanins on serum adipsin and visfatin in patients with prediabetes or newly diagnosed diabetes.

Methods: A total of 160 participants with prediabetes or newly diagnosed diabetes (40-75 years old) were given 320 mg anthocyanins or placebo daily for 12 weeks in a randomized trial. Serum adipsin, serum visfatin, lipids and glycated hemoglobin A1c (HbA1c) were measured. The areas under the curve (AUCs) for glucose, insulin and C-peptide were determined before-and after-treatment by a standard 3-h 75 g oral glucose tolerance test (OGTT).

Results: Relatively significant increases in serum adipsin (net change 0.15 µg/mL [0.03, 0.27], p = 0.018) and decreases in visfatin (-3.5 ng/mL [-6.69, -0.31], p = 0.032) were observed between the anthocyanins and placebo groups. We also observed significant improvements in HbA1c (-0.11% [-0.22, -0.11], p = 0.033), apolipoprotein A-1 (apo A-1) (0.12 g/L [0.03, 0.21], p = 0.012) and apolipoprotein B (apo B) (-0.07 g/L [-0.14, -0.01], p = 0.033) in response to the anthocyanins intervention.

Conclusion: Purified anthocyanins supplementation for 12 weeks increased serum adipsin and decreased serum visfatin in patients with prediabetes or newly diagnosed diabetes. Trial registration ClinicalTrials.gov, identifier: NCT02689765.

Keywords: Adipsin; Anthocyanin; Visfatin.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Anthocyanins
  • Blood Glucose
  • Complement Factor D
  • Diabetes Mellitus, Type 2* / drug therapy
  • Glycated Hemoglobin A
  • Humans
  • Middle Aged
  • Nicotinamide Phosphoribosyltransferase
  • Prediabetic State* / diagnosis
  • Prediabetic State* / drug therapy

Substances

  • Anthocyanins
  • Blood Glucose
  • Glycated Hemoglobin A
  • Nicotinamide Phosphoribosyltransferase
  • Complement Factor D

Associated data

  • ClinicalTrials.gov/NCT02689765