Association between metabolic syndrome and gestational diabetes mellitus in women and their children: a systematic review and meta-analysis

doi:10.1007/s12020-020-02492-1

Meta-Analysis

. 2021 Feb;71(2):310-320.

doi: 10.1007/s12020-020-02492-1. Epub 2020 Sep 15.

Association between metabolic syndrome and gestational diabetes mellitus in women and their children: a systematic review and meta-analysis

Maleesa M Pathirana^{1

2}, Zohra S Lassi^{1

2}, Anna Ali^{3

4}, Margaret A Arstall^{2

5}, Claire T Roberts^{1

6}, Prabha H Andraweera^{7

8}

Affiliations

¹ Adelaide Medical School and Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia.
² Faculty of Health and Medical Sciences, Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
³ Health Performance and Policy Research Unit, Basil Hetzel Institute, The University of Adelaide, Adelaide, SA, Australia.
⁴ Adelaide G-TRAC Centre and CRE Frailty and Healthy Ageing Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
⁵ Department of Cardiology, Lyell McEwin Hospital, Elizabeth Vale, SA, Australia.
⁶ Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, 5042, Australia.
⁷ Adelaide Medical School and Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia. prabha.andraweera@adelaide.edu.au.
⁸ Department of Cardiology, Lyell McEwin Hospital, Elizabeth Vale, SA, Australia. prabha.andraweera@adelaide.edu.au.

PMID: 32930949
DOI: 10.1007/s12020-020-02492-1

Meta-Analysis

Association between metabolic syndrome and gestational diabetes mellitus in women and their children: a systematic review and meta-analysis

Maleesa M Pathirana et al. Endocrine. 2021 Feb.

. 2021 Feb;71(2):310-320.

doi: 10.1007/s12020-020-02492-1. Epub 2020 Sep 15.

Authors

Maleesa M Pathirana^{1

2}, Zohra S Lassi^{1

2}, Anna Ali^{3

4}, Margaret A Arstall^{2

5}, Claire T Roberts^{1

6}, Prabha H Andraweera^{7

8}

Affiliations

¹ Adelaide Medical School and Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia.
² Faculty of Health and Medical Sciences, Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
³ Health Performance and Policy Research Unit, Basil Hetzel Institute, The University of Adelaide, Adelaide, SA, Australia.
⁴ Adelaide G-TRAC Centre and CRE Frailty and Healthy Ageing Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
⁵ Department of Cardiology, Lyell McEwin Hospital, Elizabeth Vale, SA, Australia.
⁶ Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, 5042, Australia.
⁷ Adelaide Medical School and Robinson Research Institute, The University of Adelaide, Adelaide, SA, 5005, Australia. prabha.andraweera@adelaide.edu.au.
⁸ Department of Cardiology, Lyell McEwin Hospital, Elizabeth Vale, SA, Australia. prabha.andraweera@adelaide.edu.au.

PMID: 32930949
DOI: 10.1007/s12020-020-02492-1

Abstract

Purpose: The primary aim of this systematic review and meta-analysis was to determine the association between gestational diabetes mellitus (GDM) and metabolic syndrome (MetS) in women and children. Our secondary aim was to assess the development of MetS with respect to the elapsed time postpartum at which MetS was diagnosed.

Methods: This review is registered with PROSPERO (CRD42020173319). PubMed, CINHAL, SCOPUS, and EMBASE databases were searched. Studies reporting on the rate of MetS in pregnant women with GDM, the rate of MetS in women with a history of GDM, and the rate of MetS in offspring exposed to GDM in utero compared to healthy controls were selected.

Results: We identified 588 articles from the literature search. Fifty-one studies were included in the review and of those 35 were included in the meta-analysis. Quantitative summary measures showed that women with a history of GDM had an increased risk of developing MetS compared to those without a history of GDM (RR 2.36, 95% CI 1.77-3.14, 29 studies, 13,390 participants; heterogeneity: χ² p < 0.00001; I² = 93%). Offspring exposed to GDM in utero have an increased risk of developing MetS compared to those not exposed to GDM in utero. (RR 2.07, 95% CI 1.26-3.42, three studies, 4,421 participants; heterogeneity: χ² p = 0.33; I² = 12%). Women diagnosed with GDM have an increased risk of developing MetS during pregnancy (RR 20.51, 95% CI 5.04-83.55; three studies, 406 participants; heterogeneity: χ² p = 0.96; I² = 0%). Subgroup analysis revealed that MetS is diagnosed as early as <1 year postpartum in women with a history of GDM.

Conclusions/interpretation: Women with GDM have an increased risk of developing MetS during pregnancy. Women with a history of GDM and offspring exposed to GDM in utero have higher risks of developing MetS compared to those with no history of GDM. Metabolic syndrome in women with a history of GDM is seen as early as <1 year postpartum.

Keywords: Childhood obesity; Gestational diabetes; Metabolic syndrome; Women’s health.

PubMed Disclaimer

Cited by

Interventions in preconception and pregnant women at risk of gestational diabetes; a systematic review and meta-analysis of randomised controlled trials.
Quotah OF, Andreeva D, Nowak KG, Dalrymple KV, Almubarak A, Patel A, Vyas N, Cakir GS, Heslehurst N, Bell Z, Poston L, White SL, Flynn AC. Quotah OF, et al. Diabetol Metab Syndr. 2024 Jan 4;16(1):8. doi: 10.1186/s13098-023-01217-4. Diabetol Metab Syndr. 2024. PMID: 38178175 Free PMC article. Review.
Identify gestational diabetes mellitus by deep learning model from cell-free DNA at the early gestation stage.
Wang Y, Sun P, Zhao Z, Yan Y, Yue W, Yang K, Liu R, Huang H, Wang Y, Chen Y, Li N, Feng H, Li J, Liu Y, Chen Y, Shen B, Zhao L, Yin C. Wang Y, et al. Brief Bioinform. 2023 Nov 22;25(1):bbad492. doi: 10.1093/bib/bbad492. Brief Bioinform. 2023. PMID: 38168840 Free PMC article.
Anxiety and Depression in Early Gestation and the Association with Subsequent Gestational Diabetes Mellitus in a Disadvantaged Population.
Pathirana MM, Andraweera PH, Leemaqz S, Aldridge E, Arstall MA, Dekker GA, Roberts CT. Pathirana MM, et al. Matern Child Health J. 2023 Dec;27(12):2185-2193. doi: 10.1007/s10995-023-03778-2. Epub 2023 Oct 12. Matern Child Health J. 2023. PMID: 37823988 Free PMC article.
The association of breast feeding for at least six months with hemodynamic and metabolic health of women and their children aged three years: an observational cohort study.
Pathirana MM, Andraweera PH, Aldridge E, Harrison M, Harrison J, Leemaqz S, Arstall MA, Dekker GA, Roberts CT. Pathirana MM, et al. Int Breastfeed J. 2023 Jul 19;18(1):35. doi: 10.1186/s13006-023-00571-3. Int Breastfeed J. 2023. PMID: 37468924 Free PMC article.
The effect of circulating adiponectin levels on incident gestational diabetes mellitus: systematic review and meta‑analysis.
Gao S, Su S, Zhang E, Zhang Y, Liu J, Xie S, Yue W, Liu R, Yin C. Gao S, et al. Ann Med. 2023 Dec;55(1):2224046. doi: 10.1080/07853890.2023.2224046. Ann Med. 2023. PMID: 37318118 Free PMC article. Review.

See all "Cited by" articles

References

1. International Diabetes Federation, IDF Diabetes Atlas (International Diabetes Federation, Belgium, 2017)
1. P.H. Andraweera, G.A. Dekker, M. Arstall, T. Bianco-Miotto, C.T. Roberts, Complications of pregnancy and future cardiovascular risk. in Encylopedia of Cardiovascular Research and Medicine, (eds D.B. Sawyer, R.S. Vasan) vol. 1 (Oxford, The Netherlands, 2018), pp. 643–650
1. L. Bellamy, J.P. Casas, A.D. Hingorani, D. Williams, Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 373(9677), 1773–1779 (2009). https://doi.org/10.1016/s0140-6736(09)60731-5 - DOI - PubMed
1. A. Lorenzo-Almorós, T. Hang, C. Peiró, L. Soriano-Guillén, J. Egido, J. Tuñón, Ó. Lorenzo, Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases. Cardiovasc. Diabetol. 18(1), 140 (2019). https://doi.org/10.1186/s12933-019-0935-9 - DOI - PubMed - PMC
1. K.G. Alberti, P.Z. Zimmet, Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet. Med. 15(7), 539–553 (1998). https://doi.org/10.1002/(sici)1096-9136(199807)15:7<539::Aid-dia668>3.0.Co;2-s - DOI - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- Genetic Alliance
- MedlinePlus Health Information

[1] International Diabetes Federation, IDF Diabetes Atlas (International Diabetes Federation, Belgium, 2017)

[2] International Diabetes Federation, IDF Diabetes Atlas (International Diabetes Federation, Belgium, 2017)

[3] P.H. Andraweera, G.A. Dekker, M. Arstall, T. Bianco-Miotto, C.T. Roberts, Complications of pregnancy and future cardiovascular risk. in Encylopedia of Cardiovascular Research and Medicine, (eds D.B. Sawyer, R.S. Vasan) vol. 1 (Oxford, The Netherlands, 2018), pp. 643–650

[4] P.H. Andraweera, G.A. Dekker, M. Arstall, T. Bianco-Miotto, C.T. Roberts, Complications of pregnancy and future cardiovascular risk. in Encylopedia of Cardiovascular Research and Medicine, (eds D.B. Sawyer, R.S. Vasan) vol. 1 (Oxford, The Netherlands, 2018), pp. 643–650

[5] L. Bellamy, J.P. Casas, A.D. Hingorani, D. Williams, Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 373(9677), 1773–1779 (2009). https://doi.org/10.1016/s0140-6736(09)60731-5 - DOI - PubMed

[6] L. Bellamy, J.P. Casas, A.D. Hingorani, D. Williams, Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 373(9677), 1773–1779 (2009). https://doi.org/10.1016/s0140-6736(09)60731-5 - DOI - PubMed

[7] A. Lorenzo-Almorós, T. Hang, C. Peiró, L. Soriano-Guillén, J. Egido, J. Tuñón, Ó. Lorenzo, Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases. Cardiovasc. Diabetol. 18(1), 140 (2019). https://doi.org/10.1186/s12933-019-0935-9 - DOI - PubMed - PMC

[8] A. Lorenzo-Almorós, T. Hang, C. Peiró, L. Soriano-Guillén, J. Egido, J. Tuñón, Ó. Lorenzo, Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases. Cardiovasc. Diabetol. 18(1), 140 (2019). https://doi.org/10.1186/s12933-019-0935-9 - DOI - PubMed - PMC

[9] K.G. Alberti, P.Z. Zimmet, Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet. Med. 15(7), 539–553 (1998). https://doi.org/10.1002/(sici)1096-9136(199807)15:7<539::Aid-dia668>3.0.Co;2-s - DOI - PubMed

[10] K.G. Alberti, P.Z. Zimmet, Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet. Med. 15(7), 539–553 (1998). https://doi.org/10.1002/(sici)1096-9136(199807)15:7<539::Aid-dia668>3.0.Co;2-s - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Association between metabolic syndrome and gestational diabetes mellitus in women and their children: a systematic review and meta-analysis

Affiliations

Association between metabolic syndrome and gestational diabetes mellitus in women and their children: a systematic review and meta-analysis

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Medical