Diverse roles of phosphatidate phosphatases in insect development and metabolism

Insect Biochem Mol Biol. 2021 Jun:133:103469. doi: 10.1016/j.ibmb.2020.103469. Epub 2020 Sep 12.

Abstract

The conversion of the glycerophospholipid phosphatidic acid (PA) into diacylglycerol (DAG) is essential for the biosynthesis of membrane phospholipids and storage fats. Importantly, both PA and DAG can also serve signaling functions in the cell. The dephosphorylation of PA that yields DAG can be executed by two different classes of enzymes, Mg2+-dependent lipins and Mg2+-independent lipid phosphate phosphatases. Here, I will discuss the current status of research directed at understanding the roles of these enzymes in insect development and metabolism. Special emphasis will be given to studies in the model organism Drosophila melanogaster.

Keywords: Lazaro; Lipid phosphate phosphatases; Lipins; Nutrient signaling; Phosphatidate phosphatases; Wunen.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / metabolism
  • Insecta / metabolism*
  • Lipid Metabolism
  • Membrane Proteins / metabolism
  • Phosphatidate Phosphatase / metabolism*
  • Phosphatidic Acids / metabolism
  • Phospholipids / metabolism
  • Phosphoric Monoester Hydrolases / metabolism
  • Signal Transduction

Substances

  • Drosophila Proteins
  • Membrane Proteins
  • Phosphatidic Acids
  • Phospholipids
  • laza protein, Drosophila
  • lipid phosphate phosphatase
  • Phosphoric Monoester Hydrolases
  • Phosphatidate Phosphatase
  • wun protein, Drosophila