Milk Exosomes: Perspective Agents for Anticancer Drug Delivery

doi:10.3390/ijms21186646

Review

. 2020 Sep 11;21(18):6646.

doi: 10.3390/ijms21186646.

Milk Exosomes: Perspective Agents for Anticancer Drug Delivery

Sergey Sedykh^{1

2}, Anna Kuleshova^{1

2}, Georgy Nevinsky^{1

2}

Affiliations

¹ SB RAS Institute of Chemical Biology and Fundamental Medicine, 630090 Novosibirsk, Russia.
² Faculty of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.

PMID: 32932782
PMCID: PMC7555228
DOI: 10.3390/ijms21186646

Free PMC article

Review

Milk Exosomes: Perspective Agents for Anticancer Drug Delivery

Sergey Sedykh et al. Int J Mol Sci. 2020.

Free PMC article

. 2020 Sep 11;21(18):6646.

doi: 10.3390/ijms21186646.

Authors

Sergey Sedykh^{1

2}, Anna Kuleshova^{1

2}, Georgy Nevinsky^{1

2}

Affiliations

¹ SB RAS Institute of Chemical Biology and Fundamental Medicine, 630090 Novosibirsk, Russia.
² Faculty of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.

PMID: 32932782
PMCID: PMC7555228
DOI: 10.3390/ijms21186646

Abstract

Exosomes are biological nanovesicles that participate in intercellular communication by transferring biologically active chemical compounds (proteins, microRNA, mRNA, DNA, and others). Due to their small size (diameter 40-100 nm) and high biological compatibility, exosomes are promising delivery tools in personalized therapy. Because artificial exosome synthesis methods are not developed yet, the urgent task is to develop an effective and safe way to obtain exosomes from natural sources. Milk is the only exosome-containing biological fluid that is commercially available. In this regard, milk exosomes are unique and promising candidates for new therapeutic approaches to treating various diseases, including cancer. The appearance of side effects during the use of cytotoxic and cytostatic agents is among the main problems in cancer chemotherapy. According to this, the targeted delivery of chemotherapeutic agents can be a potential solution to the toxic effect of chemotherapy. The ability of milk exosomes to carry out biologically active substances to the cell makes them promising tools for oral delivery of chemotherapeutic agents. This review is devoted to the methods of milk exosome isolation, their biological components, and prospects for their use in cancer treatment.

Keywords: cancer; drug delivery; exosomes; isolation; milk; milk exosomes; vesicles.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Cited by

Potential therapeutic effects of milk-derived exosomes on intestinal diseases.
Cui Z, Amevor FK, Zhao X, Mou C, Pang J, Peng X, Liu A, Lan X, Liu L. Cui Z, et al. J Nanobiotechnology. 2023 Dec 20;21(1):496. doi: 10.1186/s12951-023-02176-8. J Nanobiotechnology. 2023. PMID: 38115131 Free PMC article. Review.
Milk Exosomes: Next-Generation Agents for Delivery of Anticancer Drugs and Therapeutic Nucleic Acids.
Timofeeva AM, Paramonik AP, Sedykh SS, Nevinsky GA. Timofeeva AM, et al. Int J Mol Sci. 2023 Jun 15;24(12):10194. doi: 10.3390/ijms241210194. Int J Mol Sci. 2023. PMID: 37373342 Free PMC article. Review.
Comparison of proteomic landscape of extracellular vesicles in pleural effusions isolated by three strategies.
Yao X, Liao B, Chen F, Liu L, Wu K, Hao Y, Li Y, Wang Y, Fan R, Yin J, Liu L, Guo Y. Yao X, et al. Front Bioeng Biotechnol. 2023 Apr 12;11:1108952. doi: 10.3389/fbioe.2023.1108952. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 37122867 Free PMC article.
Analysis of Proteins and Peptides of Highly Purified CD9⁺ and CD63⁺ Horse Milk Exosomes Isolated by Affinity Chromatography.
Sedykh SE, Purvinsh LV, Burkova EE, Dmitrenok PS, Ryabchikova EI, Nevinsky GA. Sedykh SE, et al. Int J Mol Sci. 2022 Dec 17;23(24):16106. doi: 10.3390/ijms232416106. Int J Mol Sci. 2022. PMID: 36555744 Free PMC article.
Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection.
Santos-Coquillat A, Herreros-Pérez D, Samaniego R, González MI, Cussó L, Desco M, Salinas B. Santos-Coquillat A, et al. Biol Direct. 2022 Nov 14;17(1):31. doi: 10.1186/s13062-022-00345-7. Biol Direct. 2022. PMID: 36376978 Free PMC article.

See all "Cited by" articles

References

1. Cintio M., Polacchini G., Scarsella E., Montanari T., Stefanon B., Colitti M. MicroRNA Milk Exosomes: From Cellular Regulator to Genomic Marker. Animals. 2020;10:1126. doi: 10.3390/ani10071126. - DOI - PMC - PubMed
1. Colombo M., Raposo G., Théry C. Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles. Annu. Rev. Cell Dev. Biol. 2014;30:255–289. doi: 10.1146/annurev-cellbio-101512-122326. - DOI - PubMed
1. Sawada S.I., Sato Y.T., Kawasaki R., Yasuoka J.I., Mizuta R., Sasaki Y., Akiyoshi K. Nanogel hybrid assembly for exosome intracellular delivery: Effects on endocytosis and fusion by exosome surface polymer engineering. Biomater. Sci. 2020;8:619–630. doi: 10.1039/C9BM01232J. - DOI - PubMed
1. Bunggulawa E.J., Wang W., Yin T., Wang N., Durkan C., Wang Y., Wang G. Recent advancements in the use of exosomes as drug delivery systems. J. Nanobiotechnol. 2018;16:81. doi: 10.1186/s12951-018-0403-9. - DOI - PMC - PubMed
1. Admyre C., Johansson S.M., Qazi K.R., Filén J.-J., Lahesmaa R., Norman M., Neve E.P.A., Scheynius A., Gabrielsson S. Exosomes with immune modulatory features are present in human breast milk. J. Immunol. 2007;179:1969–1978. doi: 10.4049/jimmunol.179.3.1969. - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources

[1] Cintio M., Polacchini G., Scarsella E., Montanari T., Stefanon B., Colitti M. MicroRNA Milk Exosomes: From Cellular Regulator to Genomic Marker. Animals. 2020;10:1126. doi: 10.3390/ani10071126. - DOI - PMC - PubMed

[2] Cintio M., Polacchini G., Scarsella E., Montanari T., Stefanon B., Colitti M. MicroRNA Milk Exosomes: From Cellular Regulator to Genomic Marker. Animals. 2020;10:1126. doi: 10.3390/ani10071126. - DOI - PMC - PubMed

[3] Colombo M., Raposo G., Théry C. Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles. Annu. Rev. Cell Dev. Biol. 2014;30:255–289. doi: 10.1146/annurev-cellbio-101512-122326. - DOI - PubMed

[4] Colombo M., Raposo G., Théry C. Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles. Annu. Rev. Cell Dev. Biol. 2014;30:255–289. doi: 10.1146/annurev-cellbio-101512-122326. - DOI - PubMed

[5] Sawada S.I., Sato Y.T., Kawasaki R., Yasuoka J.I., Mizuta R., Sasaki Y., Akiyoshi K. Nanogel hybrid assembly for exosome intracellular delivery: Effects on endocytosis and fusion by exosome surface polymer engineering. Biomater. Sci. 2020;8:619–630. doi: 10.1039/C9BM01232J. - DOI - PubMed

[6] Sawada S.I., Sato Y.T., Kawasaki R., Yasuoka J.I., Mizuta R., Sasaki Y., Akiyoshi K. Nanogel hybrid assembly for exosome intracellular delivery: Effects on endocytosis and fusion by exosome surface polymer engineering. Biomater. Sci. 2020;8:619–630. doi: 10.1039/C9BM01232J. - DOI - PubMed

[7] Bunggulawa E.J., Wang W., Yin T., Wang N., Durkan C., Wang Y., Wang G. Recent advancements in the use of exosomes as drug delivery systems. J. Nanobiotechnol. 2018;16:81. doi: 10.1186/s12951-018-0403-9. - DOI - PMC - PubMed

[8] Bunggulawa E.J., Wang W., Yin T., Wang N., Durkan C., Wang Y., Wang G. Recent advancements in the use of exosomes as drug delivery systems. J. Nanobiotechnol. 2018;16:81. doi: 10.1186/s12951-018-0403-9. - DOI - PMC - PubMed

[9] Admyre C., Johansson S.M., Qazi K.R., Filén J.-J., Lahesmaa R., Norman M., Neve E.P.A., Scheynius A., Gabrielsson S. Exosomes with immune modulatory features are present in human breast milk. J. Immunol. 2007;179:1969–1978. doi: 10.4049/jimmunol.179.3.1969. - DOI - PubMed

[10] Admyre C., Johansson S.M., Qazi K.R., Filén J.-J., Lahesmaa R., Norman M., Neve E.P.A., Scheynius A., Gabrielsson S. Exosomes with immune modulatory features are present in human breast milk. J. Immunol. 2007;179:1969–1978. doi: 10.4049/jimmunol.179.3.1969. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Milk Exosomes: Perspective Agents for Anticancer Drug Delivery

Affiliations

Milk Exosomes: Perspective Agents for Anticancer Drug Delivery

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources