The effect of hepcidin on components of metabolic syndrome in chronic kidney disease: a cross-sectional study

Rev Assoc Med Bras (1992). 2020 Aug;66(8):1100-1107. doi: 10.1590/1806-9282.66.8.1100.


Background: Hepcidin is an important regulator of iron homeostasis.

Objectives: This cross-sectional study was conducted to evaluate the association between hepcidin and components of metabolic syndrome in patients with chronic kidney disease (CKD).

Design and setting: 103 CKD patients and 59 healthy volunteers were included in the study from the University Hospital.

Methods: Serum hepcidin levels were measured by enyzme-linked immunosorbent assay (ELISA) test. As for the study parameters, age, sex, body mass index, renal diseases, serum biochemistry, complete blood count, iron and total iron-binding capacity, ferritin, high-sensitive C-reactive protein (hsCRP), C- reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated.

Results: The mean age of the patients was 58.63 ± 11.8 years. Hepcidin level was significantly associated with hypertension and higher uric acid levels (P < 0.05). There was a positive correlation between hepcidin and urea, uric acid, creatinine, ferritin, CRP, ESR, phosphorus, triglyceride, low-density lipoprotein (LDL), proteinuria and albuminuria in 24-hour urine collection. A negative correlation was found between hepcidin and estimated glomerular filtration rate (eGFR), hemoglobin, hematocrit, calcium, 25 OH vitamin D, pH, and bicarbonate levels.

Conclusion: Hepcidin, a well-known hormone regulator of iron metabolism, may play an important role in the pathogenesis of metabolic syndrome in patients with CKD, and further studies might delineate in-depth its potential as a promising early marker in these patients.

MeSH terms

  • Aged
  • Cross-Sectional Studies
  • Glomerular Filtration Rate
  • Hepcidins
  • Humans
  • Metabolic Syndrome*
  • Middle Aged
  • Renal Insufficiency, Chronic


  • Hepcidins