Induction and transmission of oncogene-induced senescence

Cell Mol Life Sci. 2021 Feb;78(3):843-852. doi: 10.1007/s00018-020-03638-0. Epub 2020 Sep 16.


Senescence is a cellular stress response triggered by diverse stressors, including oncogene activation, where it serves as a bona-fide tumour suppressor mechanism. Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. Secondary senescence was initially described as a paracrine mechanism, but recent evidence suggests a more complex scenario involving juxtacrine communication between cells. In addition, single-cell studies described differences between primary and secondary senescent end-points, which have thus far not been considered functionally distinct. Here we discuss emerging concepts in senescence transmission and heterogeneity in primary and secondary senescence on a cellular and organ level.

Keywords: Juxtacrine senescence; Notch signalling; Oncogene-induced senescence; Secondary senescence.

Publication types

  • Review

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Protein-beta / metabolism
  • Cellular Senescence / physiology*
  • Humans
  • Jagged-1 Protein / metabolism
  • Oncogenes / genetics*
  • Paracrine Communication
  • Receptors, Notch / metabolism
  • Signal Transduction
  • Transforming Growth Factor beta / metabolism


  • CCAAT-Enhancer-Binding Protein-beta
  • Jagged-1 Protein
  • Receptors, Notch
  • Transforming Growth Factor beta