Dopamine modifies the balance of rod and cone inputs to horizontal cells of the Xenopus retina

Brain Res. 1988 May 24;449(1-2):332-6. doi: 10.1016/0006-8993(88)91048-7.

Abstract

Dopamine (greater than or equal to 2 microM) increased the cone input and suppressed the rod input to axon-bearing horizontal cells of the Xenopus retina. Dopamine (10 microM) also depolarized the horizontal cell by about 9 mV. The D2-dopamine antagonists spiperone and metoclopramide had the opposite action to dopamine, whereas the D1-dopamine antagonist SCH 23390 was without effect. None of the agents tested modified the light-evoked responses of rods.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Benzazepines / pharmacology
  • Dopamine / pharmacology*
  • Dopamine Antagonists
  • Evoked Potentials
  • Membrane Potentials / drug effects
  • Metoclopramide / pharmacology
  • Photic Stimulation
  • Photoreceptor Cells / drug effects
  • Photoreceptor Cells / physiology*
  • Retina / physiology*
  • Retinal Ganglion Cells / drug effects
  • Retinal Ganglion Cells / physiology*
  • Spiperone / pharmacology
  • Xenopus

Substances

  • Benzazepines
  • Dopamine Antagonists
  • Spiperone
  • Metoclopramide
  • Dopamine