•Psychological well-being of cancer patients can be jeopardized by the challenges derived from the COVID-19 pandemic.
•Cancer nurses are at the frontline in managing patients care between in-hospital services and home-based cancer management.
•Nurses could assess cancer patients’ psychological need and identify pathways to improve psychological well-being to ensure continuity of care.
•Patients with cancer may require greater psychological support when self-isolated.
Keywords: COVID-19; Nursing; Psychological well-being.