Hypothetical interpretation of the calcium paradox in renin secretion

Cell Tissue Res. 1988 Jun;252(3):687-90. doi: 10.1007/BF00216658.


Most renin-positive cells of the preglomerular arteriole are intermediate in morphological appearence between smooth muscle cells and epithelioid cells. Intermediate cells contain, in addition to secretory granules, contractile proteins arranged as a sublemmal network. The paradoxical (inhibitory) role of calcium in renin secretion is explained, on the basis of these findings, by an increased tone of the sublemmal network; this might impair the preexocytotic access of renin granules to the cell membrane.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / physiology*
  • Kidney / blood supply
  • Kidney / enzymology*
  • Kidney / ultrastructure
  • Microscopy, Electron
  • Models, Biological*
  • Rats
  • Renin / metabolism*


  • Renin
  • Calcium