brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans

Cell. 1988 Jul 29;54(3):353-62. doi: 10.1016/0092-8674(88)90198-5.


The brlA gene of A. nidulans mediates the developmental switch from the indeterminate, apical growth pattern of vegetative cells to the budding growth pattern of conidiophores. brlA encodes a 432 amino acid polypeptide containing two directly repeated motifs resembling the Zn(II) coordination sites first recognized in Xenopus TFIIIA. Misscheduled expression of brlA in vegetative cells results in transcriptional activation of developmentally regulated genes, cessation of unidirectional hyphal growth, initiation of cellular transformations resembling those that occur during normal conidiophore development, and production of viable conidiospores. We propose that BRLA is a nucleic acid-binding protein whose expression in vegetative cells is sufficient to induce sporulation through its role in regulating expression of conidiation-specific genes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Aspergillus nidulans / genetics*
  • Aspergillus nidulans / growth & development
  • Aspergillus nidulans / physiology
  • Base Sequence
  • Cloning, Molecular
  • DNA, Fungal / genetics
  • Fungal Proteins / genetics*
  • Gene Expression Regulation
  • Genes, Fungal
  • Molecular Sequence Data
  • Mutation
  • RNA, Fungal / genetics
  • RNA, Messenger / genetics
  • Spores, Fungal
  • Transcription Factors*
  • Transcription, Genetic
  • Transformation, Genetic


  • BRLA protein, Emericella nidulans
  • DNA, Fungal
  • Fungal Proteins
  • RNA, Fungal
  • RNA, Messenger
  • Transcription Factors

Associated data

  • GENBANK/M20631