COVID-19 and Diabetes: A Collision and Collusion of Two Diseases

Diabetes. 2020 Dec;69(12):2549-2565. doi: 10.2337/dbi20-0032. Epub 2020 Sep 16.

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has infected >22.7 million and led to the deaths of 795,000 people worldwide. Patients with diabetes are highly susceptible to COVID-19-induced adverse outcomes and complications. The COVID-19 pandemic is superimposing on the preexisting diabetes pandemic to create large and significantly vulnerable populations of patients with COVID-19 and diabetes. This article provides an overview of the clinical evidence on the poorer clinical outcomes of COVID-19 infection in patients with diabetes versus patients without diabetes, including in specific patient populations, such as children, pregnant women, and racial and ethnic minorities. It also draws parallels between COVID-19 and diabetes pathology and suggests that preexisting complications or pathologies in patients with diabetes might aggravate infection course. Finally, this article outlines the prospects for long-term sequelae after COVID-19 for vulnerable populations of patients with diabetes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Blood Glucose
  • COVID-19 / complications*
  • Comorbidity
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / therapy
  • Humans
  • Risk Factors
  • SARS-CoV-2*

Substances

  • Blood Glucose