Minimally Invasive Microbiopsies as an Improved Sampling Method for the Diagnosis of Cutaneous Leishmaniasis

Open Forum Infect Dis. 2020 Aug 17;7(9):ofaa364. doi: 10.1093/ofid/ofaa364. eCollection 2020 Sep.

Abstract

Current sampling methods to diagnose cutaneous leishmaniasis are invasive and painful. An alternative and minimally invasive microbiopsy device was evaluated in a diverse range of cutaneous leishmaniasis lesions in Ethiopia. Using polymerase chain reaction-based diagnosis, the microbiopsy outperformed the routine skin slit sample by detecting more patients while pain scores were significantly lower.

Keywords: Leishmania aethiopica; cutaneous leishmaniasis; diagnosis; sample collection.