Microneedling in vitiligo: A systematic review

Dermatol Ther. 2020 Nov;33(6):e14297. doi: 10.1111/dth.14297. Epub 2020 Sep 23.


Microneedling was initially introduced for skin rejuvenation; however, this minimally invasive procedure is now being used for the treatment of multiple dermatological conditions. Recent reports have shown its efficacy in the treatment of vitiligo. This review analyzes the current literature on microneedling techniques, efficacy, and safety for vitiligo treatment. An extensive PubMed was done to identify the literature on microneedling treatment for vitiligo. Case reports, case series, and clinical trials were included in this review. All 14 articles evaluated showed improvement of vitiligo lesions after microneedling treatment. The combination of microneedling and topical tacrolimus, 5-fluorouracil, topical calcipotriol and betamethasone, narrowband ultraviolet B with or without photodynamic therapy, and triamcinolone acetonide solution yielded more efficacy than microneedling monotherapy. Microneedling is a safe and efficient technique in the treatment of vitiligo. Thus, it can be an alternative treatment for vitiligo especially when the latter is resistant to conventional therapies.

Keywords: microneedling; vitiligo.

Publication types

  • Systematic Review

MeSH terms

  • Combined Modality Therapy
  • Humans
  • Skin Pigmentation
  • Tacrolimus
  • Treatment Outcome
  • Vitiligo* / diagnosis
  • Vitiligo* / therapy


  • Tacrolimus