SARS-CoV-2-induced immunodysregulation and the need for higher clinical suspicion for co-infection and secondary infection in COVID-19 patients

Allison Parrill; Tiffany Tsao; Vinh Dong; Nguyen Tien Huy

doi:10.1016/j.jmii.2020.08.016

SARS-CoV-2-induced immunodysregulation and the need for higher clinical suspicion for co-infection and secondary infection in COVID-19 patients

J Microbiol Immunol Infect. 2021 Feb;54(1):105-108. doi: 10.1016/j.jmii.2020.08.016. Epub 2020 Sep 8.

Authors

Allison Parrill¹, Tiffany Tsao¹, Vinh Dong¹, Nguyen Tien Huy²

Affiliations

¹ American University of Caribbean, School of Medicine, Sint Maarten.
² School of Tropical Medicine and Global Health, Nagasaki University, Japan; Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam. Electronic address: tienhuy@nagasaki-u.ac.jp.

Abstract

Cases of co-infection and secondary infection emerging during the current Coronavirus Disease-19 (COVID-19) pandemic are a major public health concern. Such cases may result from immunodysregulation induced by the SARS-CoV-2 virus. Pandemic preparedness must include identification of disease natural history and common secondary infections to implement clinical solutions.

Keywords: COVID-19 [Supplementary Concept]; Co-infection; Immunosuppression; Lymphopenia; Superinfection.

MeSH terms

COVID-19 / epidemiology
COVID-19 / immunology*
COVID-19 / microbiology*
COVID-19 / virology
Coinfection / epidemiology
Coinfection / immunology*
Coinfection / virology*
Humans
Immunosuppression Therapy
Lymphopenia / immunology
Lymphopenia / microbiology
Lymphopenia / virology
Pandemics
Prevalence
Public Health
SARS-CoV-2 / immunology*
Superinfection / immunology
Superinfection / microbiology
Superinfection / virology