Orthotopic Liver Transplantation for Etanercept-induced Acute Hepatic Failure: A Case Report

Iran J Pathol. 2020 Fall;15(4):338-341. doi: 10.30699/ijp.2020.117000.2269. Epub 2020 Jul 16.


Occurrence of hepatotoxicity following prescription of etanercept, a tumor necrosis factor-alpha (TNF-α) antagonist, is a relatively well-known issue. On the other hand, acute hepatic failure which could lead to liver transplantation is extremely rare to the best of our knowledge, and there is no previously published case in the literature. In this article, we presented a case of acute liver failure followed by liver transplantaion, in a 32- year old man with a previous history of ankylosing spondylitis after etanercept usage. On pathologic examination of the explanted liver of the patient, extensive confluent necrosis in all liver segments with prominent infiltration of a mixed population of inflammatory cells in portal tracts was noticed. In conclusion, close follow-up of patients who are receiving etanercept is crucial, since its liver complications could be severe enough to subject the patients for liver transplantation.

Keywords: Autoimmunity; Etanercept; Hepatic failure; Hepatitis; Liver transplantation.

Publication types

  • Case Reports