Delayed Presentation of Drug-Induced Hepatic Injury

Shohana Ahmed; Nirmal K Onteddu; Ali Jabur; Sai Swarupa R Vulasala; Swapna Kolli

doi:10.7759/cureus.9713

Delayed Presentation of Drug-Induced Hepatic Injury

Cureus. 2020 Aug 13;12(8):e9713. doi: 10.7759/cureus.9713.

Authors

Shohana Ahmed¹, Nirmal K Onteddu², Ali Jabur¹, Sai Swarupa R Vulasala³, Swapna Kolli⁴

Affiliations

¹ Internal Medicine, Texas Tech University Health Sciences Center at Permian Basin, Odessa, USA.
² Internal Medicine/Hospitalist, Flowers Hospital, Dothan, USA.
³ Medicine, Sri Venkateswara Medical College, Tirupati, IND.
⁴ Internal Medicine, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, USA.

Abstract

Drug-induced hepatotoxicity is a major cause of acute liver failure (ALF) in the United States. There are many offending agents like prescription drugs and herbal remedies. However, the most common prescription medication involved worldwide is amoxicillin-clavulanate. We report an unusually delayed presentation of severe cholestatic hepatitis caused by amoxicillin-clavulanate in a 20-year-old female with worsening hyperbilirubinemia that was successfully treated with corticosteroids and ursodeoxycholic acid (UDCA).

Keywords: amoxicillin – clavulanate; drug-induced liver disease; udca therapy.

Publication types

Case Reports