Unbiased translation proteomics upon cell stress

Mol Cell Oncol. 2020 May 18;7(4):1763150. doi: 10.1080/23723556.2020.1763150. eCollection 2020.


The mammalian target of rapamycin and the integrated stress response are central cellular hubs regulating translation upon stress. The precise proteins and pathway specificity of translation targets of these pathways remained largely unclear. We recently described a new method for quantitative translation proteomics and found that both pathways control translation of the same sets of proteins.

Keywords: ISR; Translation proteomics; integrated stress response; mTOR; proteostasis; stress; translatome.

Grant support

C.M. was supported by the European Research Council (ERC StG 803565), the Emmy Noether Program (DFG, MU 4216/1-1), and the Johanna Quandt Young Academy at Goethe.