Acute oxygen therapy: a cross-sectional study of prescribing practices at an English hospital immediately before COVID-19 pandemic

Expert Rev Respir Med. 2021 Feb;15(2):277-284. doi: 10.1080/17476348.2021.1826316. Epub 2020 Oct 14.

Abstract

Background: Approximately 14% of UK hospital in-patients receive supplemental oxygen therapy, only 57% have valid prescriptions. Oxygen must be optimally prescribed to ensure maximal therapeutic response whilst minimizing adverse outcomes (including fatality). This study investigates prescription compliance.

Methods: All adults admitted to medical wards (18 February to 3 March 2020) were included. Analyses present proportions, descriptive statistics, and hypothesis testing. Ethical approval was unnecessary for this audit.

Results: Of the 636 patients admitted, 66 (10%) were receiving oxygen therapy. Ages ranged from 34 to 100 years with 36 (54.5%) males and 30 (45.5%) females. The prescription was not documented in the oxygen section of the drug chart (n = 37, 56.1%, p = 0.389), nor did it have the physicians signature (n = 40, 60.6%, p = 0.110) nor date (n = 46, 69.7%, p = 0.002). Thirteen chronic obstructive pulmonary disease (COPD) patients (19.7%) were at risk of hypercapnic failure (p = 1.582x10-6). Target oxygen saturation (SpO2) range had been documented for 30 (45.5%) patients. A target SpO2 range of 88-92% was documented for 9 patients (13.6%), a 94-98% range documented for 11 patients (16.7%). All patients had an invalid prescription.

Conclusion: We present real-world practice in naturalistic settings, immediately before pandemic-lockdown. Enhanced compliance is advocated to reduce risks of harm and mortality.

Keywords: Oxygen; chronic obstructive; dyspnea; hypercapnia; hypoxia; iatrogenic disease; inpatients; oximetry; oxygen inhalation therapy; pulmonary disease.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • COVID-19 / epidemiology
  • Clinical Audit*
  • Community-Acquired Infections / therapy
  • Cross-Sectional Studies
  • Documentation / statistics & numerical data*
  • Electronic Health Records
  • Female
  • Hospitalization*
  • Humans
  • Hypercapnia / etiology
  • Male
  • Middle Aged
  • Oxygen / blood
  • Oxygen Inhalation Therapy / statistics & numerical data*
  • Pandemics
  • Pulmonary Disease, Chronic Obstructive / blood
  • Pulmonary Disease, Chronic Obstructive / therapy
  • Respiratory Insufficiency / therapy
  • United Kingdom / epidemiology

Substances

  • Oxygen