Multilevel modelling of the risk of malaria among children aged under five years in Nigeria

Trans R Soc Trop Med Hyg. 2021 May 8;115(5):482-494. doi: 10.1093/trstmh/traa092.

Abstract

Background: Malaria is still a major cause of morbidity and mortality among children aged <5 y (U5s). This study assessed individual, household and community risk factors for malaria in Nigerian U5s.

Methods: Data from the Nigerian Malaria Health Indicator Survey 2015 were pooled for analyses. This comprised a national survey of 329 clusters. Children aged 6-59 mo who were tested for malaria using microscopy were retained. Multilevel logit model accounting for sampling design was used to assess individual, household and community factors associated with malaria parasitaemia.

Results: A total of 5742 children were assessed for malaria parasitaemia with an overall prevalence of 27% (95% CI 26 to 28%). Plasmodium falciparum constituted 98% of the Plasmodium species. There was no significant difference in parasitaemia between older children and those aged ≤12 mo. In adjusted analyses, rural living, northwest region, a household size of >7, dependence on river and rainwater as primary water source were associated with higher odds of parasitaemia, while higher wealth index, all U5s who slept under a bed net and dependence on packaged water were associated with lower odds of parasitaemia.

Conclusion: Despite sustained investment in malaria control and prevention, a quarter of the overall study population of U5s have malaria. Across the six geopolitical zones, the highest burden was in children living in the poorest rural households.

Keywords: Children aged <5 y; Malaria; Nigeria; insecticide-treated bed net; parasitaemia.

MeSH terms

  • Adolescent
  • Child
  • Cross-Sectional Studies
  • Humans
  • Infant
  • Malaria* / epidemiology
  • Nigeria / epidemiology
  • Parasitemia / epidemiology
  • Plasmodium*
  • Prevalence